Journal
AUDIOLOGY AND NEURO-OTOLOGY
Volume 7, Issue 3, Pages 171-174Publisher
KARGER
DOI: 10.1159/000058305
Keywords
gentamicin; kanamycin; reactive oxygen species; antioxidants; protection
Funding
- NIDCD NIH HHS [DC-03685, R01 DC003685] Funding Source: Medline
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Studies over the last decade have left little doubt that reactive oxygen species (ROS) participate in the cellular events leading to aminoglycoside-induced hearing loss. The evidence ranges from the demonstration of aminoglycoside-mediated ROS formation in vitro to the prevention of oxotoxicity by antioxidants in guinea pig in vivo. Here we review a hypothesis of the mechanism of toxicity, discuss possible causes underlying the gradient in base-to-apex sensitivity of outer hair cells, and present recent results on the adult mouse as a new animal model of aminoglycoside ototoxicity and its prevention. Copyright (C) 2002 S. Karger AG, Basel.
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