Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 77, Issue 3, Pages 389-401Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/nlme.2001.4037
Keywords
fear; anxiety; rats; hippocampus; excitotoxic; memory; kainate; schizophrenia
Funding
- NIMH NIH HHS [MH 01109] Funding Source: Medline
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Previous research has shown that hippocampal lesions impair the expression of fear conditioning. This fear conditioning deficit may be due to memory impairment or a reduction in fear in lesioned animals. To address these possibilities, the authors examined unconditioned and conditioned fear in male Sprague-Dawley rats that had received intracerebroventricular (ICV) infusions of kainic acid (KA) 30 days prior to testing. Animals that had received bilateral ICV infusions of KA (1.0 mul of 0.8 mg/ml solution per side) exhibited cell loss that was primarily confined to the CA3 region of the dorsal hippocampus. Kainic acid lesions impaired contextual and cued fear conditioning but did not affect unconditioned fear in a light:dark test of anxiety. Moreover, animals with KA lesions did not habituate to the light:dark apparatus when tested over a 3-day period. These data suggest that decreases in fear conditioning produced by hippocampal lesions reflect a memory deficit and not a lack of fear. (C) 2001 Elsevier Science (USA).
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