Journal
GENESIS
Volume 33, Issue 1, Pages 21-28Publisher
WILEY-LISS
DOI: 10.1002/gene.10081
Keywords
segmentation clock; somite formation; presomitic mesoderm; fringe genes; Radical fringe knockout mice
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Funding
- NCI NIH HHS [CA34196] Funding Source: Medline
- NINDS NIH HHS [NS36437] Funding Source: Medline
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The Notch signaling pathway is important in regulating formation and anterior-posterior patterning of somites in vertebrate embryos. Here we show that distinct segmentation defects are displayed in embryos mutant for the Notch pathway genes Notch1, Lunatic fringe (Lfng), Delta-like 1 (Dll1), and Delta-like 3 (Dll3). Lfng-deficient mice and Dll3-deficient mice exhibit very similar defects, and marker analysis suggests that progression of the segmentation clock is disrupted in Dll3 mutants. We also show that Radical fringe (Rfng)-deficient mice exhibit no obvious phenotypic defects. To assess whether the absence of a phenotype in Rfng-deficient mice was the result of functional redundancy with the Lfng gene, we generated Lfng/Rfng double homozygous mutant mice. These mice exhibit the skeletal defects normally observed in Lfng-deficient mice, but we detected no obvious synergistic or additive effects in the double mutant animals. genesis 33:21-28, 2002. (C) 2002 Wiley-Liss, Inc.
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