Journal
BLOOD
Volume 99, Issue 9, Pages 3472-3475Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.V99.9.3472
Keywords
-
Categories
Ask authors/readers for more resources
Point mutations were found in the adenosine triphosphate (ATP) binding region of BCR/ABL In 12 of 18 patients with chronic myelold leukemia (CML) or Ph-positive cute lymphoblastic leukemia (Ph+ ALL) and imatinib resistance (defined as loss of established hematologic response), but they were found In only 1 of 10 patients with CML with Imatinib refractoriness (failure to achieve cytogenetic response). in 10 of 10 patients for whom samples were available, the mutation was not detected before the initiation of imatinib therapy. Three mutations (T3151, Y253H, and F317L present in 3, 1, and 1 patients, respectively) have a predicted role in abrogating Imatinib binding to BCR/ABL, whereas 3 other mutations (E255K, G250E, and M351T present in 4, 2, and 2 patients, respectively) do not. Thus we confirm a high frequency of mutations clustered within the ATP-binding region of BCR/ABL in resistant patients. Screening may allow Intervention before relapse by Identifying emerging mutations with defined impacts on Imatinib binding. Certain mutations may respond to higher doses of imatinib, whereas other mutations may mandate switching to another therapeutic strategy. (C) 2002 by The American Society of Hematology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available