Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 13, Issue 5, Pages 1641-1651Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.02-01-0008
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Funding
- NIGMS NIH HHS [T32 GM007737, 5T32GM07737] Funding Source: Medline
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Ovulation in Caenorizabditis elegans requires inositol 1,4,5-triphosphate (IP3) signaling activated by the epidermal growth factor (EGF)-receptor homolog LET-23. We generated a deletion mutant of a type I 5-phosphatase, ipp-5, and found a novel ovulation phenotype whereby the spermatheca hyperextends to engulf two oocytes per ovulation cycle. The temporal and spatial expression of IPP-5 is consistent with its proposed inhibition of IP3 signaling in the adult spermatheca. ipp-5 acts downstream of let-23, and interacts with let-23-mediated IP3 signaling pathway genes. We infer that IPP-5 negatively regulates IP3 signaling to ensure proper spermathecal contraction.
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