Facile Pd-catalyzed cross-coupling of 2′-deoxyguanosine O6-arylsulfonates with arylboronic acids

[GRAPHIC] The O-6-(2-mesitylenesulfonyl) derivative of 2'-deoxyguanosine undergoes a facile palladium-mediated C-C cross-coupling with arylboronic acids. Demonstrating the general applicability of this method, the synthesis of a previously undescribed class of 2-amino-6-arylpurine 2'-deoxynucleosides has been accomplished. The study also describes an evaluation of the O-6-(2,4,6-trilsopropylphenylsulfonyl) and the O-6-(4-toluenesulfonyl) derivatives for the cross-coupling.