Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 195, Issue 9, Pages 1145-1154Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20011284
Keywords
chemokines; chemokine receptors; chemotaxis; mobilization; bone marrow
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Funding
- NCI NIH HHS [T32 CA009151, 5T32CA09151] Funding Source: Medline
- NHLBI NIH HHS [R01 HL058770, 5R01 HL58770] Funding Source: Medline
- NIAID NIH HHS [AI47822, R37 AI047822, T32 AI007290, 5T32 AI-07290, R01 AI047822, R21 AI047822] Funding Source: Medline
- NIGMS NIH HHS [R37 GM037734, GM37734, R01 GM037734] Funding Source: Medline
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Although hematopoietic stern cell (HSC) migration into and out of sites of active hematopoiesis is poorly understood, it is a critical process that underlies modern clinical stern cell transplantation and may be important for normal hematopoietic homeostasis. Given the established roles of chemotactic cytokine (chemokine)-directed migration of other leukocyte subsets, the migration of murine HSC to a large panel of CC and CXC chemokines was investigated. HSC migrated only in response to stromal derived factor-la, the ligand for the CXC chemokine receptor 4 (CXCR4). CXCR4 expression by HSC was confirmed by reverse transcription polymerase chain reaction analysis. Surprisingly, HSC also expressed mRNA for CCP3 and CCR9, although they failed to migrate to the ligands for these receptors. The sharply restricted chemotactic responsiveness of HSC is unique among leukocytes and may be necessary for the specific homing of circulating HSC to bone marrow, as well as for the maintenance of HSC in hematopoietic microenvironments.
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