Journal
NEUROREPORT
Volume 13, Issue 6, Pages 857-860Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200205070-00024
Keywords
c-Fos; cholera toxin; circadian; paraventricular nucleus; subparaventricular
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Funding
- NINDS NIH HHS [R01 NS40788] Funding Source: Medline
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The suprachiasmatic nucleus (SCN) is the site of a circadian clock with input (afferent) pathways for photic entrainment and output (efferent) pathways for expression of overt, measurable rhythms. To determine whether there are individual neurons in the mouse SCN that might be part of both pathways, we performed double-label immunohistochemistry for light induced c-Fos and the retrograde tracer cholera toxin subunit B (CtB), 2 weeks after CtB was iontophoresed into the subparaventricular area (subPVA). A minority of neurons was found that were both efferent to the subPVA and responsive to light. This cellular subset may function as a direct channel through the SCN for photic inputs to influence neural outputs, and its existence highlights the topographical heterogeneity of SCN tissue. NeuroReport 13:857-860 (C) 2002 Lippincott Williams Wilkins.
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