Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 442, Issue 3, Pages 231-235Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(02)01550-9
Keywords
methamphetamine; locomotor activity; place preference; sex; (rat)
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The effects of methamphetamine were tested in male and female rats on two different behavioral tasks. Following habituation to a locomotor activity chamber, female rats were more sensitive to the locomotor activating effect of i.p. methamphetamine (0.1-3.0 mg/kg) than were male rats. A similar effect has been observed for other psychomotor stimulants, including cocaine and amphetamine. However, males and females did not differ on methamphetamine-induced place preference following eight conditioning trials with a wide range of doses (0.1-5.6 mg/kg). These results suggest that males and females differ in their response to methamphetamine for only some behavioral tasks. Published by Elsevier Science B.V.
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