Journal
ONCOGENE
Volume 21, Issue 21, Pages 3459-3474Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1205327
Keywords
apoptosis; programmed cell death; malignancy
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Ever since the discovery of Bel-2 and the elucidation of its role in apoptosis, tremendous interest has arisen in prospects for triggering suicide of malignant cells by exploiting knowledge emerging from apoptosis research. In this review, we summarize information about the multiple genetic lesions which have been identified in apoptosis-regulatory genes of hematopoietic and lymphoid neoplasms. Emerging data about the structural and biochemical details of apoptosis proteins and their upstream regulators have reveal novel strategies for therapeutic intervention, some of which are under interrogation in clinical trials currently.
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