Journal
VACCINE
Volume 20, Issue 17-18, Pages 2166-2173Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(02)00112-3
Keywords
vaccination; pneumococcal; review
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Pneumococcal polysaccharide vaccine is recommended in western countries for individuals at high risk of pneumococcal illness. We undertook a systematic review of randomised controlled trials of pneumococcal vaccine in adults, to determine the effects on clinical outcomes. Results: In industrialised populations, no benefit was detected for outcomes other than pneumococcal bacteraemia, and thin, did not reach statistical significance. In non-industrial populations, clear benefit was demonstrated for mortality and all-cause pneumonia. Conclusion: Benefit from pneumococcal vaccination depends on the baseline risk of infection and characteristics of a given population. Evidence from randomised trials for widespread adult vaccination in industrial countries is lacking. (C) 2002 Elsevier Science Ltd. All rights reserved.
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