Journal
ORGANIC LETTERS
Volume 4, Issue 11, Pages 1859-1862Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol025829s
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[GRAPHICS] Hydroxylation of N-substituted azetidines 11 and 12 and piperidines 15-19 with Sphingomonas sp. HXN-200 gave 91-98% of the corresponding 3-hydroxyazetidines 13 and 14 and 4-hydroxypiperidines 20-24, respectively, with high activity and excellent regioselectivity. High yields and high product concentrations (2 g/L) were achieved with frozen/thawed cells as biocatalyst. For the first time, rehydrated lyophilized cells were successfully used for the biohydroxylation.
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