Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 67, Issue 11, Pages 3718-3723Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo011116w
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Funding
- NIGMS NIH HHS [GM 45970] Funding Source: Medline
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Starting from optically active 3,3-difluorolactaldehyde, an alkenyl or aryl boronic acid, and an amine, a one-step three-component methodology was developed for the stereoselective preparation of anti-alpha-(difluoromethyl)-beta-amino alcohols. beta-Furyl-substituted anti-alpha-(difluoromethyl)-beta-amino alcohol was further elaborated to form (2S,3R)-difluorothreonine in high yield and ee.
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