Journal
CELL
Volume 109, Issue 5, Pages 625-637Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(02)00754-7
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Funding
- NCI NIH HHS [R01 CA075072-03, CA 75072, P01 CA072006, P01 CA072006-07, CA 72006] Funding Source: Medline
- NHLBI NIH HHS [R01 HL061849, HL-66592, P01 HL067839, HL-61849, HL-67839, HL-58707] Funding Source: Medline
- NIAMS NIH HHS [R01 AR046238, AR 46238, R01 AR046238-06A2] Funding Source: Medline
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Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals. Matrix metalloproteinase-9 (MMP-9), induced in BM cells, releases soluble Kit-ligand (sKitL), permitting the transfer of endothelial and hematopoietic stem cells (HSCs) from the quiescent to proliferative niche. BM ablation induces SDF-1, which upregulates MMP-9 expression, and causes shedding of sKitL and recruitment of c-Kit(+) stem/progenitors. In MMP-9(-/-) mice, release of sKitL and HSC motility are impaired, resulting in failure of hematopoietic recovery and increased mortality, while exogenous sKitL restores hematopoiesis and survival after BM ablation. Release of sKitL by MMP-9 enables BM repopulating cells to translocate to a permissive vascular niche favoring differentiation and reconstitution of the stem/progenitor cell pool.
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