Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 277, Issue 22, Pages 19831-19838Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M109613200
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Funding
- NEI NIH HHS [R01 EY011307, EY11307] Funding Source: Medline
- NIA NIH HHS [AG19206] Funding Source: Medline
- NINDS NIH HHS [NS41449] Funding Source: Medline
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Molecular chaperones are involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. DnaK- and DnaJ-Iike proteins are the two major classes of molecular chaperones in mammals. Recent studies have shown that DnaJ-Iike family proteins can inhibit polyglutamine aggregation, a hallmark of many neurodegenerative diseases, including Huntington's disease (HD). Although most DnaJ-Iike proteins studied are ubiquitously expressed, some have restricted expression, so it is possible that some specific chaperones may affect polyglutamine aggregation in specific neurons. In this report, we describe the isolation of a DnaJ-Iike protein MRJ and the characterization of its chaperone activity. Tissue distribution studies showed that MRJ is highly enriched in the central nervous system. In an in vitro cell model of HD, over-expressed MRJ effectively suppressed polyglutamine-dependent protein aggregation, caspase activity, and cellular toxicity. Collectively, these results suggest that MRJ has a relevant functional role in neurons.
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