Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 32, Issue 11, Pages 1050-1060Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(02)00794-3
Keywords
free radicals; amyloid beta-peptide; neurotoxicity; protein oxidation; lipid peroxidation
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Amyloid beta-peptide (Abeta) is heavily deposited in the brains of Alzheimer's disease (AD) patients, and free radical oxidative stress, particularly of neuronal lipids and proteins, is extensive. Recent research suggests that these two observations may be linked by Abeta-induced oxidative stress in AD brain. This review summarizes current knowledge on phospholipid peroxidation and protein oxidation in AD brain, one potential cause of this oxidative stress, and consequences of Abeta-induced lipid peroxidation and protein oxidation in AD brain. (C) 2002 Elsevier Science Inc.
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