Journal
JOURNAL OF IMMUNOLOGY
Volume 168, Issue 11, Pages 5566-5572Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.168.11.5566
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Funding
- NIAID NIH HHS [AI35917, T32-AI07080, F32-AI10431] Funding Source: Medline
- NIDDK NIH HHS [DK45260] Funding Source: Medline
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IL-2 is a cytokine produced primarily by activated T cells and is thought to be the quintessential T cell growth factor. The precise role of IL-2 in the regulation of CD8 T cell responses to foreign Ag in vivo however remains enigmatic. Using an adoptive transfer system with IL-2- or IL-2R-deficient TCR transgenic CD8 T cells and MHC class I tetramers, we demonstrated that the expansion of antiviral CD8 T cells in secondary lymphoid tissues was IL-2 independent, whereas IL-2 played a more significant role in supporting the continued expansion of these cells within nonlymphoid tissues. Paradoxically, autocrine IL-2 negatively regulated the overall magnitude of the CD8 T cell response in nonlymphoid tissues via a Fas-independent mechanism. Furthermore, autocrine IL-2 did not regulate the contraction or memory phase of the response. These experiments identified a novel role for IL-2 in regulation of antiviral CD8 T cell responses and homeostasis in nonlymphoid tissues.
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