Journal
MODERN PATHOLOGY
Volume 15, Issue 6, Pages 673-678Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/modpathol.3880585
Keywords
CD99; Ewing's sarcoma; meninges; peripheral primitive neuroectodermal tumor; t(11;22)
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We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.
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