Journal
THEORETICAL POPULATION BIOLOGY
Volume 61, Issue 4, Pages 481-487Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/tpbi.2002.1594
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Making accurate functional predictions for genes is a key step in this era of high throughput gene and genome sequencing. While most functional prediction methods are comparative in nature, many do not take advantage of the power that an evolutionary perspective provides to any comparative biology analysis. Here we review how evolutionary analysis can greatly benefit both homology-based and non-homology-based functional prediction methods. Examples that are discussed include phylogenetic determination of orthology, the use of character state reconstruction analysis of gene function, and evolutionary analysis of rates and patterns of gene evolution. (C) 2002 Elsevier Science (USA).
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