Journal
LEUKEMIA
Volume 16, Issue 6, Pages 1053-1068Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.leu.2402482
Keywords
nuclear factor kappa B (NF-kappa B); I kappa B kinase (IKK); inflammation; cancer; drug development; apoptosis
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Funding
- NCI NIH HHS [P01 CA91844] Funding Source: Medline
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Nuclear factor kappa B (NF-kappaB) is a family of inducible transcription factors found virtually ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been discovered about its mechanisms of activation, its target genes, and its function in a variety of human diseases including those related to inflammation, asthma, atherosclerosis, AIDS, septic shock, arthritis, and cancer. Due to its role in a wide variety of diseases, NF-kappaB has become one of the major targets for drug development. Here, we review our current knowledge of NF-kappaB, the possible mechanisms of its activation, its potential role in cancer, and various strategies being employed to target the NF-kappaB signaling pathway for cancer drug development.
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