Journal
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Volume 72, Issue 6, Pages 691-700Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp.72.6.691
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Funding
- NIA NIH HHS [P01 AG019724] Funding Source: Medline
- NIMH NIH HHS [MH19938] Funding Source: Medline
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The four major degenerative dementias that often begin in presenescence: are reviewed. These are Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, and Creutzfeldt-Jakob disease. Their epidemiological, genetic, and clinical features are reviewed, and controversies in taxonomy arising from recent discoveries described. Particular attention is given to the pathological role of protein aggregation, which appears to be a factor in each disease.
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