Journal
AGEING RESEARCH REVIEWS
Volume 1, Issue 3, Pages 465-479Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S1568-1637(02)00012-0
Keywords
ageing; cataract; conformational disease; alpha-crystallin; post-translational modification of proteins; unfolding
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Many late-life diseases are conformational diseases in tissues where there are unfolded or mis-folded proteins which can form aggregates. These diseases have other common features in their aetiology. Cataract is one such disease and post-translational modifications of proteins in the lens during cataract formation are described as a possible guide to the changes in other age-related conditions. Delineation of common pathways in these diseases could lead to common treatment regimes, and in this respect, there are promising results for aspirin-like drugs in Alzheimer's disease, cataract, myocardial infarction, stroke and various cancers. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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