Journal
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
Volume 1, Issue 3, Pages 205-209Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/153303460200100305
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Funding
- University of South Florida
- Center for Molecular Delivery
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Interferon a may be used as a single agent therapy for metastatic malignant melanoma or as an adjuvant to chemotherapy. Delivery of interferon a by gene therapy offers an alternative to recombinant protein therapy. Electrically mediated delivery enhances plasmid expression in a number of tissues, for instance skin, liver, muscle and tumors including melanomas. Here we compare the effect of delivery of a plasmid encoding mouse interferon a on growth of visible B16 mouse melanomas following electrically mediated delivery to muscle or directly to the tumor. Intratumoral delivery of interferon a plasmid not only slows melanoma growth, but induces complete, long term, regression. This effect was not observed after intramuscular delivery.
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