Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 14, Issue 3, Pages 357-364Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(02)00329-0
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The nuclear lamina is composed of both A- and B-type lamins and lamin-binding proteins, Many lamin-binding proteins are integral proteins of the inner nuclear membrane. Lamins and inner nuclear membrane proteins are important for a variety of cell functions, including nuclear assembly, replication, transcription, and nuclear integrity. Recent advances in the field in the past year include the identification of a family of spectrin-repeat-containing inner nuclear membrane proteins and other novel inner-membrane proteins, and the discovery of a nuclear membrane fusion complex. There is also growing evidence that A- and B-type lamins and their binding partners have distinct roles during nuclear assembly and interphase.
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