Journal
GYNECOLOGIC ONCOLOGY
Volume 85, Issue 3, Pages 517-523Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/gyno.2002.6665
Keywords
carboplatin; cyclophosphamide; intraperitoneal; ovarian cancer; paclitaxel; kinetic modeling
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Objective. The purpose of this study was to determine the efficacy, tolerability, and pharmacokinetics of intraperitoneal (ip) paclitaxel combined with intravenous (iv) carboplatin and cyclophosphamide. Patients and methods. Twenty-five newly diagnosed patients with Stage IC-IV epithelial ovarian cancer received ip paclitaxel with iv carboplatin and cyclophosphamide as a first-line treatment. Paclitaxel pharmacokinetics was determined during the first cycle on day 1 or 8. Results. This regimen was well tolerated, as abdominal pain and hematological toxicities were minor, while neurotoxicity grade 1/11 was reported in only 20% and myalgia in 24% of patients and were fully reversible. After treatment 13 of 18 (72%) of the patients a no evidence of disease. At a median follow-up of 30 months patients with residual disease after surgery (n = 10) had a median progression-free survival (PSF) of 13 months; for the optimally debulked group (n = 15) the actuarial PFS was 60% at 48 months. The elimination of paclitaxel from the peritoneal cavity and plasma followed first-order kinetics and was not influenced by adding carboplatin with cyclophosphamide. Conclusion. This regimen was well tolerated, with minimal hematologic or neurotoxicity, and allowed the application of a triple-drug schedule without compromising dose intensity. To judge its efficacy, comparison with a standard iv paclitaxel-based schedule should be performed in a formal phase III study. (C) 2002 Elsevier Science (USA).
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