Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 50, Issue 6, Pages 844-846Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.50.844
Keywords
Haplophyllum; tissue culture; lignan; cytotoxicity
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A new arylnaphthalene lignan glycoside, patavine (1), together with five known lignans, justicidin B (2), diphyllin (3), tuberculatin (4), majidine (5), and arabelline (6) were isolated from shoot cultures of Haplophyllum patavinum. The structure of the new compound was elucidated by extensive one-dimensional (1D) and two-dimensional (2D) NMR experiments and mass spectrometry. The cytotoxicity of compounds 1, and 3-6 against LoVo human colon carcinoma cells was investigated.
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