Journal
PEPTIDES
Volume 23, Issue 6, Pages 1177-1180Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(02)00052-9
Keywords
prepro-orexin; mRNA expression; real-time PCR; hypothalamus
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The neuropeptides orexin A and B are expressed in the lateral hypothalamic area and are involved in the regulation of energy homeostasis and arousal. Recent results showed gender differences in the expression of orexin receptor subtypes in rats. In the present study, we analyzed the mRNA expression of prepro-orexin (PPO) in the hypothalamus of male and female rats using quantitative real-time PCR. We found significantly higher levels of PPO mRNA in the hypothalamus of female rats compared to male rats. Our study indicates a sex-dependent regulation of hypothalamic PPO expression and suggests gender-specific functions of orexins. (C) 2002 Elsevier Science Inc. All rights reserved.
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