Journal
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Volume 19, Issue 6, Pages 1015-1029Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2002.10506805
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A new in vitro screening method has been developed and applied to a commercial phage-displayed cDNA library to search for novel protein-protein interactions. PDZ, WW and SH3 domains from PSD95, Nedd4, Src, Abl and Crk proteins were used as targets. 12 novel putative and 2 previously reported interactions were identified in test screens. The novel screening format, dubbed TAIS (target-assisted iterative screening), is discussed as an alternative platform to existing technologies for a pair-wise characterization of protein-protein interactions.
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