Journal
NATURE GENETICS
Volume 31, Issue 2, Pages 133-134Publisher
NATURE AMERICA INC
DOI: 10.1038/ng888
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Funding
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
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We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.
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