Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 67, Issue 2, Pages 171-186Publisher
WILEY
DOI: 10.1002/jmv.2206
Keywords
arenavirus; mucosal infection; primates; vascular pathology
Categories
Funding
- NCRR NIH HHS [R01-RR13980, R01 RR013980-02, R01 RR013980-03, R01 RR013980-01] Funding Source: Medline
- NIAID NIH HHS [R01 AI052367, R01 AI052367-01A1, R01 AI052367-05, R01 AI052367-03, R01 AI052367-02, R01 AI052367-04, R01 AI032107-03] Funding Source: Medline
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Arenaviruses can cause hemorrhagic fever and death in primates and guinea pigs, but these viruses are not highly pathogenic for most rodent carriers. In the United States, arenaviruses precipitated outbreaks of hepatitis in captive monkeys, and they present an emerging health threat in the tropical areas of Africa and South America. We describe infection of rhesus macaques with the prototype arenavirus, lymphocytic choriomeningitis virus (LCMV), using the WE strain that has been known to cause both encephalopathy and multifocal hemorrhage. Five macaques were inoculated: two by the intravenous (i.v.) and three by the intragastric (i.g.) route. Whereas the two i.v.-inoculated monkeys developed signs and lesions consistent with fatal hemorrhagic fever, the i.g.-inoculated monkeys had an attenuated infection with no disease. Pathological signs of the primate i.v. infection differ significantly from guinea pig arenavirus infections and make this a superior model for human viral hemorrhagic disease. (C) 2002 Wiley-Liss, Inc.
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