Journal
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume 45, Issue 7, Pages 601-610Publisher
WILEY
DOI: 10.1002/jlcr.584
Keywords
carbon-13 labelled arenes; [1-C-13]-para-xylene; [2-C-13]-para-xylene; arenium ions; gaseous; carbon scrambling
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An efficient synthesis of [1-C-13]-para-xylene (1a) and [2-C-13]-para-xylene (1b) is described. The incorporation of the label has been achieved by cyclocondensation of suitable 1,5-bis(bromomagnesio)alkanes with either ethyl [1-C-13]acetate or ethyl [C-13]formate which gave [ring-C-13]-labelled dimethylcyclohexanols. Dehydration of these alcohols followed by dehydrogenation of the intermediate dimethylcyclohexenes furnished the title compounds in 32 and 40% overall yield, respectively. Copyright (C) 2002 John Wiley Sons, Ltd.
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