Journal
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
Volume 25, Issue 6, Pages 542-548Publisher
WICHTIG EDITORE
DOI: 10.1177/039139880202500609
Keywords
hybrid liver; bioartificial liver; ammonia; urea; glucose metabolism
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Biochemical activity of a hybrid liver support system based on porcine liver cells was investigated in patients suffering from acute liver failure, coma stage III-IV Patient plasma was drawn systemically and after circulation through the bioreactor at four hour intervals. A method is used that takes into account the rate of plasma flow and the differences in plasma concentration systemically and after circulation through the liver support system to determine the net release or uptake of metabolites such as ammonia, urea and glucose. Urea release (mean 2.28 +/- 0.37 mumol/h/g cells) and ammonia uptake (mean 0.17 +/- 0.11 mumol/h/g cells) was seen during treatment, an active role of the system in glucose metabolism was observed. All patients were bridged successfully to liver transplantation.
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