Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 12, Pages 6408-6412Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.12.6408-6412.2002
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Funding
- NIAID NIH HHS [AI48053, R01 AI048053] Funding Source: Medline
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A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.
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