Journal
AGEING RESEARCH REVIEWS
Volume 1, Issue 3, Pages 413-423Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S1568-1637(02)00009-0
Keywords
premature ovarian failure; aging; menopause
Categories
Ask authors/readers for more resources
dPremature ovarian failure (POF) is a unique example of isolated organ senescence, with a population prevalence of approximately 1%. Though the phenotypic expression of POF is similar to that of age-appropriate natural menopause, the underlying pathophysiological mechanisms are diverse and not entirely clear. The impact of POF on the patient is profound, with myriad ramifications, ranging from psychological devastation to multi-system implications of estrogen deprivation and its sequelae. The hastening of degenerative changes noted in these patients however, are not entirely ameliorated with estrogen replacement and POF may indeed represent an acceleration of the aging process. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available