Journal
MECHANISMS OF DEVELOPMENT
Volume 114, Issue 1-2, Pages 201-204Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(02)00056-4
Keywords
high in normal-1 (HIN-1); uteroglobin related protein-1 (URGP-1) uteroglobin; secretoglobin; C/EBP-delta; development; differentiation; epithelium; mammary gland; lung; Drosophila; trachea; retinoic acid
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We analyzed the expression of high in normal-1 (HIN-1), a putative breast tumor suppressor gene, and uteroglobin related protein-1 (UGRP-1), a homologue of HIN-1, in adult and developing mouse tissues. Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands. The expression of both genes was detected only at E17.5-18.5 and the HIN-1 messenger RNA was localized to the epithelia of the trachea, bronchi, and uterine glands. The expression of HIN-1 is up-regulated during retinoic acid induced differentiation of bronchial epithelial cells. We also identified two putative Drosophila HIN-1 homologues, The expression of HIN-1 is restricted to terminally differentiated airway epithelial cells in vivo and in vitro implicating HIN-1 in the acquisition or maintenance of terminally differentiated epithelial phenotype. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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