Journal
NEUROPHARMACOLOGY
Volume 42, Issue 7, Pages 873-888Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3908(02)00047-3
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The emergence of the TRP (C) and vanilloid (TRPV) receptor family of Ca2+ permeable channels has started to provide molecular focus to a linked group of ion channels whose common feature is activation primarily by intracellular ligands. These channels have a central role in Ca2+ homeostasis in virtually all cells and in particular those that lack voltage-gated Ca2+ channels. We will discuss recent work that is more precisely defining both molecular form and physiological function of this important group of Ca2+ permeable channels with particular focus Oil the intracellular ligands that gate and modulate channel activity. (C) 2002 Elsevier Science Ltd. All rights reserved.
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