Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 66, Issue 6, Pages 738-744Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2002.66.738
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Funding
- NIAID NIH HHS [P50 AI030603-05, P50-AI-30603] Funding Source: Medline
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Leishmania Viannia strains from 1,092 patients who acquired dermal leishmaniasis in endemic regions of Colombia were analyzed for expression of species and subgenus specific epitopes, Eight monoclonal antibodies prepared against membranes of the major species of the Viannia subgenus and previously shown to distinguish these species, recognized low molecular mass (< 45kD) membrane components. Thirteen widely but non-uniformly distributed serodemes were identified: one unique to L. panamensis, four unique to L. braziliensis and eight that were common to L. braziliensis and L. guyanensis. Thirty-seven percent of Colombian L. braziliensis strains concomitantly typed by isoenzymes were null, i.e., not recognized by the corresponding species-specific B-16 or B-18 antibodies. No Colombian L. guyanensis strains were recognized by the antibody specific for this species (B-19). In contrast, L. panamensis-specific B-4 and 1311 antibodies recognized > 98% of the L. panamensis strains. Null strains of L. braziliensis and L. panamensis were more frequently isolated from mucosal leishmaniasis than strains that expressed species specific epitopes, suggesting that these strains may be more pathogenic.
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