Journal
CANADIAN JOURNAL OF CHEMISTRY
Volume 80, Issue 6, Pages 646-652Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/V02-079
Keywords
dihydropyrimidinone; enzymatic resolution; palladium coupling
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The convergent synthesis of a potent alpha(1A)-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of 2,4'-dipyridyl.
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