Journal
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
Volume 55, Issue 3, Pages 200-203Publisher
BRITISH MED JOURNAL PUBL GROUP
DOI: 10.1136/mp.55.3.200
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Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes. Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines. Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a Significant increase in protein concentrations. Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway.
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