Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 12, Issue 3, Pages 315-323Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(02)00330-6
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Funding
- NINDS NIH HHS [NS15918, NS37002] Funding Source: Medline
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Investigation of the development of excitability has revealed that cells are often specialized at early stages to generate Ca2+ transients. Studies of excitability have converged on the central role of Ca2+ and K+ channels in the plasmalemma that regulate Ca2+ influx and have identified critical functions for receptor-activated channels in the endoplasmic reticulum that allow efflux of Ca2+ from intracellular stores. The parallels between excitability in these two locations motivate future work, because comparison of their properties identifies shared attributes.
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