Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 127, Issue 1-2, Pages 59-68Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00097-8
Keywords
multiple sclerosis; CXCR3; CXCL10; central nervous system; inflammation; demyelination
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Funding
- NINDS NIH HHS [P01 NS 38667] Funding Source: Medline
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T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immumohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data Suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients. (C) 2002 Elsevier Science B.V.. All rights reserved.
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