Journal
PSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 56, Issue 3, Pages 335-336Publisher
BLACKWELL PUBLISHING ASIA
DOI: 10.1046/j.1440-1819.2002.00967.x
Keywords
cholinergic neurones; laterodorsal tegmental nucleus; orexin; paradoxical sleep; pressure injection; rat; wakefulness
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Orexin, a hypothalamic neuropeptide, has been revealed to be involved in sleep regulation. To elucidate functions of orexin in brainstem sleep regulation mechanism, we examined the effects of orexin applied from micropipettes with air pressure on neurones in and around the laterodorsal tegmental nucleus (LDT). In five of seven cholinergic neurones and six of nine non-cholinergic neurones orexin induced long-lasting excitation. These results suggest that hypothalamic orexin neurones may affect the LDT neurones directly, and thereby participate in control of sleep.
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