Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 13, Issue 3, Pages 251-260Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S1084-9521(02)00052-6
Keywords
Wnt; convergent extension; planar polarity; zebrafish; Xenopus
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Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, Patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.
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