Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 132, Issue 45, Pages -Publisher
WILEY
DOI: 10.1002/app.42772
Keywords
biocompatibility; biomedical applications; hydrophilic polymers; light scattering
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Funding
- National Science Fund of Bulgaria (National Center for Advanced Materials (UNION) Module 2 New materials in medicine and pharmacy [DCVP 02-2/2009]
- Grants-in-Aid for Scientific Research [25288101] Funding Source: KAKEN
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We demonstrated a feasible approach for the preparation of a biodegradable, water soluble polyphosphoester based paclitaxel complex. Applying poly(hydroxyoxyethylene phosphate) which contains both a strong proton accepting PO group and a proton donating POH group, paclitaxel has been physically immobilized onto the polymer via H-bonding. The water soluble complex contained 16.7 wt % paclitaxel and more than 4000 times increased drug solubility was achieved. The polymer-drug complex formed nanosized aggregates that were characterized by dynamic light scattering. Intravenous injection of poly(hydroxyoxyethylene phosphate) in rats at a dose of 1000 mg/kg did not induce any clinical signs or body weight gain reduction. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42772.
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