Journal
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
Volume 15, Issue 2, Pages 61-67Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/089198870201500202
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Funding
- NIA NIH HHS [AG-10643] Funding Source: Medline
- NINDS NIH HHS [NS-35345] Funding Source: Medline
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Deficits in daytime alertness in the elderly may reflect, in part, deterioration of the critical neural systems modulating circadian control of sleep and wakefulness. In this study, 47 patients with subcortical stroke (n = 9), Alzheimer's disease (n = 6), and parkinsonism (n = 32) underwent a 24-hour in-laboratory evaluation consisting of overnight polysomnography and next-day evaluation of daytime sleep tendency with the Multiple Sleep Latency Test. Patients with stroke were significantly sleepier during the daytime relative to the Parkinson's and Alzheimer's disease patients. Nocturnal sleep parameters did not account for these differences. In the stroke patients, some infarcts occurred in the vasculature, impacting blood supply to the hypothalamus. We interpret these effects as representing functional interruptions of the suprachiasmatic nucleus (SCN). These results are also compatible with a wake-promoting function of the human SCN.
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