Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 23, Issue 6, Pages 281-287Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(02)02027-8
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The cation-pi interaction is a potent, general noncovalent binding force that is observed in a wide range of biological contexts. Here, we present an overview of well documented cases in which a cation-pi interaction makes an important contribution to small-molecule recognition at a protein binding site. From these and other studies it is clear that, in addition to the hydrophobic effect, hydrogen bonding and ion pairing, the cation-it interaction must be considered when evaluating drug-receptor interactions.
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