Journal
CRITICAL CARE MEDICINE
Volume 30, Issue 6, Pages 1204-1209Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003246-200206000-00004
Keywords
selective decontamination; liver transplantation; infection; Gram-negative bacterial infection; Gram-positive bacterial infection; fungal infection; postoperative complications; costs; cost effectiveness; colonization; sepsls
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Objective., To determine the efficacy of selective decontamination of the digestive tract (SDD) in patients undergoing elective transplantation of the liver. Design: Randomized, double-blind, placebo-controlled study. Setting. Two academic teaching hospitals. Patients. Adult patients undergoing elective liver transplantation: 26 patients receiving SDD and 29 patients receiving a placebo. Interventions: Patients undergoing SDD were administered 400 mg of norfloxacin once daily as soon as they were accepted for transplantation, Postoperative treatment for this group consisted of 2 mg of colistin, 1.8 mg of tobramycin, and 10 mg of amphotericin B, four times daily, combined with an oral paste containing a 2% solution of the same drugs until postoperative day 30. Prophylactic Intravenous administration of antibiotics was not part of the SDD regimen in this study. Control patients were given a similar regimen with placebo drugs. Measurements: The mean number of postoperative bacterial and fungal infections in the first 30 days after transplantation was the primary efficacy end point. Days on a ventilator, days spent in the intensive care unit, and medical costs were registered as secondary outcome variables. Main Results. Of the 26 patients undergoing SOD, 22 (84.5%) developed an infection in the postoperative study period; In the placebo group (n = 29), these numbers were not significantly different (25 patients, 86%). The mean number of postoperative infectious episodes per patient was also not significantly different: 1.77 (SDD) vs. 1.93 (placebo), Infections Involving Gram-negative aerobic bacteria and Candida species were significantly less frequent in patients receiving SOD (p <.001 and p <.05). Total costs were higher in the group receiving SOD. Conclusions. Selective decontamination of the digestive tract does not prevent Infection in patients undergoing elective liver transplantation and increases the cost of their care. It does, however, affect the type of infection. Infections with Gram-negative bacilli and with Candida species are replaced by infections with Gram-positive cocci.
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