Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 195, Issue 11, Pages 1387-1395Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20020656
Keywords
eosinophil; GATA-1; gene targeting; hematopoiesis; transcription
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Funding
- NCI NIH HHS [CA-82175-03] Funding Source: Medline
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Transcription factor GATA-1 reprograms immature myeloid cells to three different hematopoietic lineages-erythroid cells, megakaryocytes, and eosinophils. GATA-1 is essential for maturation of erythroid and megakaryocytic precursors, as revealed by gene targeting in mice. Here we demonstrate that deletion of a high-affinity GATA-binding site in the GATA-1 promoter, an element presumed to mediate positive autoregulation of GATA-1 expression, leads to selective loss of the eosinophil lineage. These findings suggest that GATA-1 is required for specification of this lineage during hematopoietic development. Mice lacking the ability to produce eosinophils should prove useful in ascertaining the role of eosinophils in a variety of inflammatory or allergic disorders.
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