4.5 Article

Nicotinanilides as inhibitors of neutrophil chemotaxis

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 12, Issue 11, Pages 1517-1520

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00188-9

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A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against grow-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders. (C) 2002 Elsevier Science Ltd. All rights reserved.

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