Porous structure of Purevision™ versus Focus® night&day™ and conventional hydrogel contact lenses

The surface and bulk structures of hydrogel contact lenses that contain siloxane moieties, Pure-vision(TM) (balafilcon A) and Focus(R)NightDay(TM) (lotrafilcon A), were investigated. Standard hydrogel lenses of low (Seequence(R)), medium (Acuvue(R)), and high water content (Precision UV(R)) were used as controls. All the lenses were dehydrated in a series of ethanol solutions of increased concentration, critical-point dried in CO, and sputter coated with gold/palladium before they were examined by scanning electron microscopy. Of all lenses examined, only the balafilcon lenses presented, in addition to the polymer network porosity characteristic of all hydrogels, a macroporous structure that was observed on the front and back surfaces, and in their bulk. The average diameter of the macropores appears to be much larger, from one to several orders of magnitude, than the network porosity of standard hydrogel lenses. The macropores might contribute to the gas and water permeability of these lenses, as well as to their mobility on the cornea. (C) 2002 Wiley Periodicals, Inc.